There is a release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors in the dorsal horn to lessen afferent suffering transmission and generate analgesia. For that reason, medications like clonidine that target alpha-2 receptors can influence the transmission of suffering. You could possibly notify this https://bookmarkpath.com/story19780241/5-easy-facts-about-onolidine-described