Here, we show that conolidine, a pure analgesic alkaloid Utilized in standard Chinese drugs, targets ACKR3, thus supplying additional proof of the correlation between ACKR3 and agony modulation and opening choice therapeutic avenues to the remedy of chronic agony. The initial asymmetric total synthesis of conolidine was developed by https://kenneths617hyn1.newbigblog.com/profile