In light-weight of those observations, sirtuins are recognised as novel regulators of immuno-metabolism in humans. Besides SIRT1, SIRT2 has become not long ago associated with cytoskeleton remodeling and activation of NLRP3 in intracellular pathways[117]. Besides the activation of innate immunity, the contribution of adaptive immune cells in inducing inflammation is https://www.directivepublications.org/journal-of-diabetology-research/