Our modern scientific studies point out this is due to defective trafficking of late endosomes to lysosomes, with concomitant homotypic fusion in the afflicted vesicular compartments [five]. The defect in lysosome-directed trafficking also affects autophagic flux, with resultant accumulation of autophagosomes [5]. In the long run, the integrity of the https://andyf196wbf9.wikisona.com/user